Intracranial pressure pulse amplitude during changes in head elevation: a new parameter for determining optimum cerebral perfusion pressure?

Effect of etomidate on intracranial pressure and cerebral perfusion pressure.

Ten patients with intracranial lesions, anaesthetized with thiopentone and nitrous oxide (70%) in oxygen (30%) received etomidate 0.2 mg kg-1 i.v. Ventilation was controlled in each patient. Intracranial pressure (i.c.p.) and mean arterial pressure (m.a.p.) were recorded. I.c.p. decreased significantly in all patients (0.01 greater than P greater than 0.001). Although PaCO2 decreased during the...

Cerebral perfusion pressure management of severe diffuse head injury: effect on brain compliance and intracranial pressure.

BACKGROUND Cerebral perfusion pressure management (CPPM) is an accepted modality of treatment of severe diffuse head injury (SDHI). However, CPPM has the potential to cause transcapillary exudation in the presence of a disrupted blood brain barrier and can lead to further increase of intracranial pressure (ICP) and worsening of compliance. AIMS This study attempts to evaluate the effect of bo...

Intracranial-pressure changes following head injury.

Effect of cerebral perfusion pressure on cerebral cortical microvascular shunting at high intracranial pressure in rats.

BACKGROUND AND PURPOSE Recently, we showed that decreasing cerebral perfusion pressure (CPP) from 70 mm Hg to 50 mm Hg and 30 mm Hg by increasing intracranial pressure (ICP) with a fluid reservoir induces a transition from capillary (CAP) to microvascular shunt (MVS) flow in the uninjured rat brain. This transition was associated with tissue hypoxia, increased blood-brain barrier (BBB) permeabi...

Ocular Perfusion Pressure: An Important New Parameter?

LEARNING OBJECTIVES Upon completion of this activity, participants will be able to: 1. Assess the signifi cance of ocular perfusion pressure as a risk factor for glaucoma. 2. Outline the potential role of low CSFP in the development of glaucomatous damage. 3. list the signifi cant risk factor for the development of glaucoma in patients with ocular hypertension. 4. devise appropriate management ...